05 In vitro activity.pmd

1Department of Paediatrics; 2Department of Internal Medicine; 3Department of Infection Prevention and Control, King Abdulaziz Medical City, King Fahad National Guard Hospital, Riyadh, Saudi Arabia (Correspondence to Z.A. Memish: [email protected]). 4Department of Microbiology, King Saud University, Riyadh, Saudi Arabia. 5Department of Microbiology, Qatif Central Hospital, Qatif, Saudi Arabia. 6Division of Microbiology, King Abdulaziz Medical City, King Khalid National Guard Hospital, Jeddah, Saudi Arabia. Received: 09/03/03; accepted: 02/12/03 ABSTRACT Susceptibility of 88 clinical Streptococcus pneumoniae isolates, 116 Haemophilus influenzae isolates and 80 Moraxella catarrhalis isolates to 6 fluoroquinolones—ciprofloxacin, ofloxacin, levofloxacin, trovafloxacin, grepafloxacin and gemifloxacin—were determined. Isolates were from patients with invasive disease at 4 hospitals in Saudi Arabia between 1996 and 1998. S. pneumoniae isolates were fully susceptible to trovafloxacin, grepafloxacin and gemifloxacin; susceptibility to ofloxacin and levofloxacin was 97.7% and 98.9% respectively. H. influenzae isolates were susceptible to all agents, except for trovafloxacin (99.1%). M. catarrhalis strains were fully sensitive to all agents except ofloxacin (97.5%). No isolates were resistant to gemifloxacin or grepafloxacin.